Small Dense LDL Enhances THP-1 Macrophage Foam Cell Formation
نویسندگان
چکیده
منابع مشابه
Macrophage sortilin promotes LDL uptake, foam cell formation, and atherosclerosis.
RATIONALE Noncoding gene variants at the SORT1 locus are strongly associated with low-density lipoprotein cholesterol (LDL-C) levels, as well as with coronary artery disease. SORT1 encodes a protein called sortilin, and hepatic sortilin modulates LDL metabolism by targeting apolipoprotein B-containing lipoproteins to the lysosome. Sortilin is also expressed in macrophages, but its role in macro...
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ژورنال
عنوان ژورنال: Journal of Atherosclerosis and Thrombosis
سال: 2011
ISSN: 1880-3873,1340-3478
DOI: 10.5551/jat.7161